Luca
Master Statesman
Posts: 1,317
|
Post by Luca on May 19, 2020 11:15:18 GMT -8
I agree that there are probably all kinds of physicians doing so. But not the kind who stick to reliable evidence and "primum non nocere". I hadn’t heard of the new "zinc protocol", but somehow I’m not surprised.
There are physicians who administer all sorts of unsupportable treatments, from the merely curious to the outright bizarre. But that doesn't in itself indicate that the treatments are advisable or even remotely logical. Quackery tends to expand in areas where science based medical practice is of limited use, i.e. food allergies, metastatic cancer, chronic fatigue and - in this case - COVID-19 treatment/prevention.
I’m not sure what significance you attach to the fact that you haven’t personally heard of anybody who died from hydroxychloroquine prophylaxis, but I know of many who have had very undesirable side effects taking it for even appropriate indications. I’m not sure what point you are making.
To be blunt, anecdotal evidence is like a Wabash editorial in that it’s next to useless as a guide. The Center for Evidence-Based Medicine - which makes recommendations based solely on verifiable evidence in order to weed out ineffective practices – concludes "In vivo data, although promising, is currently limited to one study with considerable limitations" and "...at present there is insufficient in vivo evidence to recommend their use for the current pandemic outside of clinical trials."
Shooting from the hip doesn't preclude success. It just makes you more prone to odd conclusions………….Luca
|
|
Luca
Master Statesman
Posts: 1,317
|
Post by Luca on May 19, 2020 11:22:47 GMT -8
Some day I'm going to have to learn how to use a computer
|
|
Credo
Master Eminence Grise
Posts: 6,242
|
Post by Credo on May 19, 2020 12:58:44 GMT -8
I'm with Luca on this one. Yes, hydroxychloroquine has been FDA-approved for 65 years as a treatment for malaria. It is prescribed over 5 million times a year, and is sometimes given to our military when they are deployed in areas where malaria is still common. But Donald Trump claims he is tested for the virus every two or three days, and the results have always been negative. So why take a drug that he doesn't need, especially given its sometimes debilitating side effects? Trump sometimes reminds me of Vilepagan - he likes to think he's an expert on everything after hearing about it or reading about on the internet. And like VP, he's often not. TDS may be getting the best of you here. Let's just imagine Donald Trump had never mentioned hydroxychloroquine. It's not as though this is some unknown drug. If anyone's personal doctor recommended it as a treatment for COVID-19 infection or because they had been exposed to--but not necessarily infected with--coronavirus, I'm guessing most people would likely take it. The President of the United States gets the best medical care in the entire world. I'll trust the physician to the President to know what he's doing. To Luca's point: I’m not sure what significance you attach to the fact that you haven’t personally heard of anybody who died from hydroxychloroquine prophylaxis, but I know of many who have had very undesirable side effects taking it for even appropriate indications. The reason I mention this is because yesterday on FOX News no less, after Trump's admission, Neil Cavuto (not a doctor as far as I know) loudly proclaimed to his audience that if you take this "YOU WILL DIE!" Those were his exact hysterical words. With all due respect, there are undesirable side effects from all sorts of medications that are taken under appropriate indications, including those which have undergone the most rigorous clinical trials and FDA approval, so that fact in itself doesn't seem significant. Jeez, practically every single pharmaceutical commercial you see on television tells you in the fine print that possible side effects include such lovely things as stroke, blindness, or death. That's why any prescription drug should only be taken in conjunction with a doctor's advice. The only reason hydroxychloroquine is considered controversial is because Donald Trump mentioned it favorably at a time when, outside medical professionals, 98% of Americans had probably never heard of it before (I certainly had not). And in the TDS environment that half the nation breathes in every day, the mere fact that Trump recommends or speaks positively about something-- anything--means that thing is automatically considered idiotic by 90% of the media and the close to 50% of the population infected with TDS. Good Lord, doctors all over American--and the world--are not prescribing hydroxychloroquine because Donald Trump first mentioned it. He could have only become aware of it through the positive results that were already being seen--and then were communicated to him. It should not be considered a valid treatment because Donald Trump says so (that would be weird); Donald Trump only said so because it is already a valid treatment. Whether it's particularly effective or not probably varies from person to person (like many drugs) is an entirely different question. This does not seem to me to be particularly difficult to see.
|
|
SK80
Master Eminence Grise
Posts: 7,378
Member is Online
|
Post by SK80 on May 19, 2020 13:36:15 GMT -8
@mdad, even you should see in the least it’s another big F U to the media and watching them now on TV.... he is #Winning again..... completely blew their minds again to the point their clown suits are splattered in media matter!!
|
|
Luca
Master Statesman
Posts: 1,317
|
Post by Luca on May 19, 2020 16:58:04 GMT -8
I can pretty much promise you that Donald Trump's physician – whoever he is – did not “recommend” taking hydroxychloroquine. This would have been Trump's decision at his insistence.
It's true that all medications have potential side effects. Therefore, before you recommend medication you assess the risks of the medication versus the known benefits of it. For patients with advanced cancer you recommend antineoplastic agents with loads of side effects, but the side effects are worth it if it is known to be effective because the alternative is very likely death. You make recommendations based on known cost and known benefit. Insofar as anyone has shown, there is no benefit to taking hydroxychloroquine but there is a risk in doing so. So the common sense recommendation is not to take it until we know there is a benefit
Your comment that "The only reason hydroxychloroquine is considered controversial is because Donald Trump mentioned it favorably" is far from the truth. The reason it's controversial is because it is merely a viral (no pun intended) Internet fantasy, there is no convincing evidence that it’s worth a damn and there are known side effects. This was widely known before Trump ever mentioned the medication. He has made it a topic of conversation, but your statement is demonstrably false. If Neil Cavuto said that he's clueless, but that’s not the issue here.
I don’t know where you’re getting your information, Credo, but I would be interested in hearing how you discovered that it is a "valid treatment." To my knowledge there was one poorly run study out of China and one small inconclusive study from a somewhat controversial physician in France. Other than that there are plenty of studies that to date are not showing any benefit. Doctors "all over America and the world" are also prescribing antibiotics for viral illness. That doesn’t make it a valid treatment. It simply points out that in medicine as in every other profession there is a bell-shaped curve of competence. Primum non nocere …………………………Luca
|
|
Credo
Master Eminence Grise
Posts: 6,242
|
Post by Credo on May 19, 2020 17:15:19 GMT -8
|
|
MDDad
Master Eminence Grise
Posts: 6,815
|
Post by MDDad on May 19, 2020 18:16:58 GMT -8
What Trump said will have repercussions no one envisioned. For example, when she hears that hydroxychloroquine is a prophylactic, AOC will run out and get some so her boyfriend doesn't have to wear a condom.
|
|
Luca
Master Statesman
Posts: 1,317
|
Post by Luca on May 19, 2020 19:16:03 GMT -8
Well that’s ridiculous. There’s no way it will prevent pregnancy...........Luca
|
|
RSM789
Eminence Grise
Posts: 2,286
|
Post by RSM789 on May 19, 2020 19:16:57 GMT -8
Dr. Kelly Victory has been on the John Phillips show 2 or 3 times a week since mid march. She is a trauma surgeon and has worked in the field of responding to mass casualties. Some of her takes on the response to Covid19 are 180 degrees from what has been accepted by much of the public.
Her take on Trump taking the drug is that if the White House doctor gave permission to take it, then most likely Trump is the right kind of candidate for it. Not currently infected with Covid19 but around dozens of different people daily. She talk of how the drug, when administered properly, does do the things needed to fight Covid19 from establishing a foothold in a persons body (I can't tell you verbatim what those things were, I'd goof it up).
I may like her because she is saying things I believe in, but she also has the credentials & common sense to explain & back them up.
|
|
Credo
Master Eminence Grise
Posts: 6,242
|
Post by Credo on May 19, 2020 20:31:07 GMT -8
I can pretty much promise you that Donald Trump's physician – whoever he is – did not “recommend” taking hydroxychloroquine. This would have been Trump's decision at his insistence. Your comment that " The only reason hydroxychloroquine is considered controversial is because Donald Trump mentioned it favorably" is far from the truth. The reason it's controversial is because it is merely a viral (no pun intended) Internet fantasy, there is no convincing evidence that it’s worth a damn and there are known side effects. This was widely known before Trump ever mentioned the medication. He has made it a topic of conversation, but your statement is demonstrably false. If Neil Cavuto said that he's clueless, but that’s not the issue here. I don’t know where you’re getting your information, Credo, but I would be interested in hearing how you discovered that it is a "valid treatment." To my knowledge there was one poorly run study out of China and one small inconclusive study from a somewhat controversial physician in France. Other than that there are plenty of studies that to date are not showing any benefit. Doctors "all over America and the world" are also prescribing antibiotics for viral illness. That doesn’t make it a valid treatment. It simply points out that in medicine as in every other profession there is a bell-shaped curve of competence. Primum non nocere …………………………Luca It would be foolish of me to dispute your medical knowledge, so let me attempt to clarify my point. I should not have used the term valid treatment, as in "hydroxy is a valid treatment for COVID-19," simply because there is--as far as I know--no "valid" drug, vaccine, or treatment for COVID-19 (hence the term novel coronavirus). I am trying to express something in layman's terms, and using the term valid has a medical connotation that you rightly pointed out is incorrect in this case. It would be better to say it is not invalid, or at least not crazy, since enough doctors have prescribed it (understanding the possible negative side effects), have seen anecdotal results, and it is the subject of several clinical trials currently looking to see if it proves effective in combatting COVID-19. Those may turn up nothing, in which case, no harm no foul. I seriously doubt the White House physician is going to take a chance on losing the President on his watch because of a mere internet rumor. Let me be clear, I am in no way recommending hydroxy, nor is Trump--he was merely giving some transparency to what he's willing to take himself under the approval of his own doctor. White House physician Dr. Sean Conley released a memo Monday evening, which said that after discussing evidence for and against hydroxychloroquine with Trump, they concluded “the potential benefit from treatment outweighed the relative risks.”
Trump said that he is also taking zinc, and that he has taken an initial dose of azithromycin, or Z-Pak.
www.cnbc.com/2020/05/19/fda-appears-to-soften-stance-on-hydroxychloroquine-after-trump-says-he-takes-malaria-drug.htmlMy point is that Trump's decision to take a drug that has been in circulation for decades and is widely prescribed in connection to malaria, lupus, and rheumatoid arthritis, and that has shown anecdotal promise in treating COVID-19 is not--as the media would have it--akin to playing Russian roulette with one's life. The media's predictable reaction is childish and irresponsible and is solely the result of their desire to discredit Trump by any means possible. It also risks casting unnecessary doubt and fear of the drug's already long-approved uses. I also appreciate the fact that he's willing to put his money where his mouth is, to "think outside the box" beyond what is merely conventional approved (though without being reckless). It's a character trait that helped him win the White House against the stale conventional thinking of the D.C. Club that most politicians epitomize...….Credo
|
|
Credo
Master Eminence Grise
Posts: 6,242
|
Post by Credo on May 19, 2020 20:46:46 GMT -8
This doesn't mean it's effective, but there's certainly interest there in the medical community.
|
|
|
Post by ProfessorFate on May 19, 2020 22:16:01 GMT -8
Dr. Kelly Victory has been on the John Phillips show 2 or 3 times a week since mid march. She is a trauma surgeon and has worked in the field of responding to mass casualties. Some of her takes on the response to Covid19 are 180 degrees from what has been accepted by much of the public. Her take on Trump taking the drug is that if the White House doctor gave permission to take it, then most likely Trump is the right kind of candidate for it. Not currently infected with Covid19 but around dozens of different people daily. She talk of how the drug, when administered properly, does do the things needed to fight Covid19 from establishing a foothold in a persons body (I can't tell you verbatim what those things were, I'd goof it up). I may like her because she is saying things I believe in, but she also has the credentials & common sense to explain & back them up. It makes it harder to penetrate the cell walls, and interferes with it's replication.
|
|
MDDad
Master Eminence Grise
Posts: 6,815
|
Post by MDDad on May 20, 2020 6:05:35 GMT -8
Dr. Kelly Victory has been on the John Phillips show 2 or 3 times a week since mid march. She is a trauma surgeon and has worked in the field of responding to mass casualties. Some of her takes on the response to Covid19 are 180 degrees from what has been accepted by much of the public. Dr. Victory is a trauma surgeon, a mass casualty expert, an epidemiologist, and was chief medical officer for Walgreen's. Compare those credentials to Dr. Zombie Barb, who is L.A. County's public health director without even having a medical degree.
|
|
Bick
Administrator
Posts: 6,901
|
Post by Bick on May 20, 2020 7:57:01 GMT -8
|
|
Bick
Administrator
Posts: 6,901
|
Post by Bick on May 20, 2020 7:59:22 GMT -8
Dr. Kelly Victory has been on the John Phillips show 2 or 3 times a week since mid march. She is a trauma surgeon and has worked in the field of responding to mass casualties. Some of her takes on the response to Covid19 are 180 degrees from what has been accepted by much of the public. Her take on Trump taking the drug is that if the White House doctor gave permission to take it, then most likely Trump is the right kind of candidate for it. Not currently infected with Covid19 but around dozens of different people daily. She talk of how the drug, when administered properly, does do the things needed to fight Covid19 from establishing a foothold in a persons body (I can't tell you verbatim what those things were, I'd goof it up). I may like her because she is saying things I believe in, but she also has the credentials & common sense to explain & back them up. I started following her on Twitter. Agree it's easier to like someone you agree with, but also opens some doors to other MDs who share the opinion.
|
|